From Center and Main Street, downtown Moab, drive approximately 4 miles south on Highway 191. Turn left into Spanish Trail Road, just in between the signs of The Branding Iron restaurant and the Shell gas station. Go straight through the 4-way stop with Spanish Valley Drive. At the roundabout (where you see the sign of the Moab Golf Club on the right) turn left into Murphy Lane. The first road to the right is Desert Hills Lane. Desert Hills B&B is the fourth house on the right.